The Role of VDR Gene Polymorphisms in Vitamin D Supplementation - Infermieristica Web

Virtual data rooms (VDRs) are secure storage facilities for data used in business transactions, legal proceedings, or IPOs. The VDR is accessible via a dedicated Internet connection that allows only authorized parties to view and modify the information. Virtual data rooms are employed by many companies in M&A transactions, since they provide security and security to exchange confidential documents.

The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling is involved a variety of biological effects that include the metabolism of calcium and phosphorous as well as parathormone release, cellular proliferation and control of adaptive and innate immunity.

A T > C alteration in the promoter of VDR variant (rs11568820) removes the binding site for transcription factor Cdx2 just upstream of exon 1. This results in a smaller protein with reduced transcriptional activity. The F allele of this variant is found at a high frequency in Asians and Europeans and at a lower frequency in Sub-Saharan Africa.

The results of this study improve our understanding of how VDR gene polymorphisms alter the response to supplements in the diet that contain calcium calcitriol. People who carry the TaqI and FF genotypes of the FokI polymorphisms show higher transcriptional activation and are associated with better calcium absorption, an increase in bone mineral density, and a reduced risk of breaking. Further research with more homogeneous designs is needed to improve our understanding of how these genetic variations influence vitamin D supplementation as well as its clinical importance.

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